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7/26/2022 · Merkel cell carcinoma (MCC) is a very rare but highly aggressive cutaneous neuroendocrine carcinoma and is associated with chronic exposure to ultraviolet light and the Merkel cell polyoma virus. The incidence rate of MCC is increasing and MCC is associated with high rates of recurrence and mortalit . A Retrospective Study of Ipilimumab Plus Nivolumab .
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7/23/2021 · Although immune checkpoint inhibitors (ICI) have become the standard of care in advanced MCC, 50% of all MCC patients are ineligible for ICIs, and amongst those treated, many patients . Selective Inhibition of Aurora Kinase A by AK01/LY Attenuates MCC Tumor Growth by Inducing MCC Cell Cycle Arrest and Apoptosis Cancers (Basel). 2021 Jul .
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After 24 h of treatment, the highest dose of MCC (50 mU/ml) decreased the proliferation rate of A549 and H520 cells, whereas the lowest dose of MCC (5 mU/ml) resulted in a small increase in the viability. A549 cells treated with MCC lost adhesion ability in a MCC dosedependent manner; however, these detached cells were able to regrow when transferred to a fresh culture. The .
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